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The Zyogreen Difference

Three ways a ready-to-use ICG is the right choice.

When the surgeon calls for ICG, Zyogreen is simpler, faster and safer.

Zyogreen carton of five 10 mL single-dose ampules with ampule
01Simpler

Less steps.
Easy to use.

Say goodbye to the reconstitution workflow. Just open the ampule, draw and administer.

Zyogreen

1Swab ampule
2Open ampule
3Draw Zyogreen with a filtered needle
4Remove filter and administer

ICG reconstituted

1Open ICG vial
2Open diluent vial
3Swab ICG vial
4Swab diluent vial
5Add diluent into ICG vial
6Mix until dissolved
7Draw reconstituted solution
8Administer

Please refer to package insert for detailed information regarding proper administration technique.

02Faster

Time savings that compound.

In fluorescence-guided surgery, the time between a surgeon’s request and ICG readiness is time the team is waiting.

22.9sec
saved on average per preparation, compared to reconstituted ICG (a 16.4% reduction in preparation time1)

Average preparation time

TIMES-ICG randomized crossover · 44 US clinicians · 176 preparations1
ICG to reconstitute2:19
Zyogreen1:56
Average time saved per preparation− 22.9 seconds (16.4%)

Mean 139.3 vs 116.4 seconds; 95% CI, 14.3–31.4 seconds; p<0.00003. Preparation time measured from start of preparation to a filled syringe.

03Safer

Manufactured under strict GMP conditions.

Ready-to-use presentations are produced at scale, under strict quality conditions, with standardized concentration in every ampule.

01

Consistent quality.

Standardized 2.5 mg/mL concentration, manufactured under strict GMP conditions in a single-dose ampule.

Every ampule, every time.
02

Fewer prep and administration errors.

Ready-to-use presentations have been associated with fewer prep and administration errors.2

Less to get wrong.
03

Less opportunity for contamination.

A sealed, ready-to-use ampule removes the vial-to-vial transfer steps where contaminants can be introduced during preparation.

Fewer open pathways.
The Zyogreen difference

Simpler. Faster. Safer.

References
  1. Data on file at Sagent.
  2. Benhamou D, Weiss M, Borms M, et al. Ann Pharmacother. 2024;58(9):921–934.
Important Safety Information

Zyogreen® (indocyanine green injection)

Indications and Usage

Zyogreen is indicated for fluorescence imaging of vessels, blood flow, and tissue perfusion; fluorescence imaging of extrahepatic biliary ducts; lymphatic mapping in cervical and uterine cancer; and ophthalmic angiography, in the populations specified in the full Prescribing Information.

Contraindications

Zyogreen is contraindicated in patients with known hypersensitivity to indocyanine green.

Warnings and Precautions

Hypersensitivity reactions, including anaphylaxis, have been reported with indocyanine green. Monitor patients for hypersensitivity and have emergency equipment and trained personnel readily available.

Adverse Reactions

The most common adverse reactions reported with indocyanine green products include hypersensitivity reactions. See full Prescribing Information for complete safety information.

To report SUSPECTED ADVERSE REACTIONS, contact Sagent Pharmaceuticals at 1-866-625-1618 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see the full Prescribing Information for additional Important Safety Information.